|
| |
Title: Galactosilated dopamine increases attention without reducing activity in C57BL/6 mice
Author: Ruocco, LA; Viggiano, D; Pignatelli, M; Lannaccone, T; Rimoli, MG; Melisi, D; Curcio, A; De Lucia, S; Carboni, E; Carnevale, UAG; de Caprariis, P; Sadile, AG
Abstract: Different strategies can be used to carry dopamine into the brain such as L-Dopa precursors or galactosilated form of DA (GAL-DA). The aim of this study was to investigate whether GAL-DA would reduce hyperactivity and increase non-selective attention (NSA) in a mouse model of attention deficit hyperactivity disorder (ADHD), as, i.e. C57BL/6 as did in NHE rats. Here we report that GAL-DA increases NSA in a spatial novelty in C57BL/6 mice. They received a single i.p. injection of GAL-DA (10 mg/kg or 100 mg/kg) or equimolar galactose vehicle. Another mouse strain the Swiss albino was introduced as inbred control group. Three hours after last injection mice were tested in a Lat-maze for 30-min. Behaviour was analyzed for horizontal (traveled distance) and vertical activity (orienting frequency and scanning durations) which shares cognitive and non-cognitive nature, respectively. Ten milligram per kilograms of GAL-DA, increases scanning duration in C57BL/6 mice. Thus a low dose of GAL-DA increases NSA without reducing hyperactivity in this mouse model of ADHD. (c) 2007 Elsevier B.V. All rights reserved.
Source: BEHAVIOURAL BRAIN RESEARCH
Publication Year: 2008
|