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Title: Short- and long-term cardiovascular effects of mixed amphetamine salts extended release in children
Author: Findling, RL; Biederman, J; Wilens, TE; Spencer, TJ; McGough, JJ; Lopez, FA; Tulloch, SJ; SLI381 301 Study Grp; 302 Study Grp
Abstract: Objective To assess the short- and long-term cardiovascular effects of once-daily treatment with a mixed amphetamine salts' extended-release formulation (MAS XR; Adderall XR (R)) in children age 6 to 12 years with attention-deficit/hyperactivity disorder (ADHD). Study design Short-term cardiovascular effects were assessed during a 4-week, double-blind, randomized, placebo-controlled, forced-dose-titration study of once-daily 10, 20, and 30 mg MAS XR (n = 580). Long-term cardiovascular effects were assessed in 568 subjects during a 2-year, open-label extension study of MAS XR (10 to 30 mg/day). Resting sitting blood pressure and pulse were measured at baseline and weeldy during the short-term study, then monthly during long-term treatment. Results Changes in blood pressure, pulse, and QT interval corrected by Bazett's formula (QTcB) in children receiving MAS XR were not statistically significantly different than those changes seen in children receiving placebo during short-term treatment. Mean, increases in blood pressure after 2 years of MAS XR treatment (systolic, 3.5 mm Hg; diastolic, 2.6 mm Hg) and pulse (3.4 bpm) were clinically insignificant, and there was no apparent dose-response relationship. Conclusions Cardiovascular effects of short- and long-term MAS XR were minimal during short- and long-term MAS XR treatment at doses of <= 30 mg/day in otherwise healthy children.
Source: JOURNAL OF PEDIATRICS
Publication Year: 2005
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